Members no alcoholic beverages practice studies (letter = 13) was excluded from the analyses

Disperse graph for participant options. Contained in this studies, we mentioned the new urinary Na/K ratio and BP into the twelve,890 members (84% regarding players were out of 2017) for two many years. Eventually, a dozen,877 users had been analyzed

Na/K ratio

Tome City requested users to collect their pee trials after waking are. The fresh urinary Na/K proportion is actually counted playing with a urinary Na/K ratio-computing equipment named HEU-001F (OMRON Medical care Co., Ltd., Kyoto, Japan) (Additional Fig. 1). The new display immediately details urinary Na/K ratio measurements. A public nurse counted the newest Na/K ratio on location pee examples of the participants having fun with the device, recorded the significance, and you may provided quick viewpoints toward users concerning your mentioned really worth along with explanatory material about the dating involving the urinary Na/K proportion and you can BP (Supplementary Fig. 2). Tome Town work fitness check-ups when you look at the each district yearly of May so you can September. Thus, professionals have its urinary Na/K ratio counted at the same time in 2017 and you can 2018.

Other measurements

Details about most other proportions is obtained from the medical checkup analysis out of Tome Area. Both body weight and body peak was indeed measured in wellness checkup. Body mass index is calculated because the lbs (kg)/peak 2 (meters 2 ). BP is mentioned twice of the a trained societal fitness nurse. Just like the wellness checkup investigation provided by Tome Town simply integrated the reduced BP dimensions of these two BP dimension beliefs, we are able to just include so it worth in our research. Hypertension was identified as systolic BP (SBP) ? 140 mmHg otherwise diastolic BP (DBP) ? ninety mmHg and you can/and/or accessibility antihypertensive cures. Information on liquor intake is actually gotten by the a questionnaire. We determined the latest alcohol intake per week as follows: i increased brand new volume off alcohol consumption (day-after-day = 7, often = step 3.5, and no chronic consuming = 0) and you may number of liquor consumed in just one celebration (0–step 1 drink = 0.5, 1–2 drinks = 1.5, 2–3 drinks = 2.5, and step 3 beverages or more = 3) and split up the item of the eight. One drink in the Japan represents 23 g regarding ethanol. Study for the the means to access all forms of diabetes medication and you can answer to cardiovascular system state was basically mind-said regarding the fitness checkup research.

With regard to details about the use of all forms of diabetes medication, people picked you to definitely choice throughout the adopting the solutions: (a) a reputation all forms of diabetes, (b) around cure for diabetes mellitus, otherwise (c) use of all forms of diabetes procedures. People who responded (c) have been categorized because “pages off diabetes cures,” whereas those who replied with (a) otherwise (b) or perhaps not appropriate had been categorized because “other people.” Regarding information about the treatment to own cardiovascular disease, users chose one to solution throughout the after the answers: (a) has actually a history of heart disease otherwise (b) receiving treatment getting heart disease. Individuals who responded (b) were categorized since “receiving treatment to own cardiovascular disease,” while people who answered that have (a) or not appropriate have been classified once the “someone else.”

Analytical analysis

To compare the difference between participants who attended health checkups both in 2017 and 2018 and those who attended health checkups only in 2017, we used the t-test for continuous variables and the chi-square test for categorical variables. For each year, we compared the baseline characteristics according to the urinary Na/K ratio level. Moreover, we analyzed the relationship between the urinary Na/K ratio and hypertension adjusted for age, sex, BMI, alcohol intake, use of diabetes medication, and treatment for heart disease. For longitudinal data, we assessed the relationship between change in urinary Na/K ratio and BP change using multiple regression analyses adjusted for age, sex, BMI change, and alcohol intake. In both cross-sectional and longitudinal analyses, we stratified the data according to the use of antihypertensive medication. We further added SBP or DBP in 2017 as a covariate. Furthermore, we analyzed the BP difference according to the urinary Na/K ratio quartile in 2017. To examine the effect of BP due to temperature, we acquired past temperature data from the Japan Meteorological Agency in 2017 and 2018 . We considered P < 0.05 as statistically significant.

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